Breast cancer is the most common cancer among women in Japan, and is expected to increase further in the future. On the other hand, the mortality rate is on a declining trend due to the increase in the screening rate and the improvement of treatment methods corresponding to the biological characteristics of breast cancer. Breast cancer can be treated with a 5-year survival rate of 90% or more if it is found in its early stages. Offering becomes important.
We strive to provide the best medical care while always considering early detection/diagnosis and treatment optimization (escalation/de-escalation) considering QOL.
Providing Reliable Healthcare
While adhering to guidelines, treatment methods are decided through consultation with individual patients and their families (shared decision making).
Providing multidisciplinary care
Through regular conferences with various staff members such as diagnostic Diagnostic Radiology, diagnostic Clinical Pathology, Radiation Oncology, Plastic Surgery, Obstetrics and Gynecology and gynecology, familial oncology outpatient department, Oncology, Palliative Care, pharmacy department, Nursing Department, etc. We provide multidisciplinary medical care through close collaboration.
Providing medical care with an emphasis on QOL
We provide treatment (supportive care) that emphasizes countermeasures against side effects caused by cancer treatment.
Providing medical care with an emphasis on aesthetics
In addition to cooperation with Plastic Surgery surgery, we perform surgery that considers the cosmetic appearance of the breast in breast-conserving surgery.
Providing highly advanced medical care
We confirm indications and provide highly advanced medical care such as clinical trials and clinical trials.
Provision of medical care utilizing hospital examinations and collaboration between hospitals and hospitals
We provide medical care that emphasizes regional cooperation according to each condition, such as a stable condition after breast cancer treatment or a terminal condition.
Medical record
Departmental statistics
Main diseases/treatments
Diagnosis flow
If you are seen (referred) with subjective symptoms such as a lump, discharge from the nipple, breast pain, etc., or if an abnormality is pointed out during a checkup.
- Following inspection and palpation, a mammogram (3D mammography (tomosynthesis)) is taken and an ultrasound examination is performed.
- Breast MRI using a contrast agent is performed for the purpose of further increasing the accuracy of diagnostic imaging.
- To confirm the diagnosis, we perform scraping cytology, fine-needle aspiration cytology, needle biopsy under local anesthesia, and excisional biopsy.
- If mammography shows calcification and a definitive diagnosis of benign or malignant is necessary, a stereo-guided mammotom is performed.
- In some cases, we may ask you to re-examine the items that were performed before visiting our hospital.
- In some cases, a tissue diagnosis is performed by inserting a thin tube from the opening of the milk duct where secretion is coming out, injecting a dye through it, and extracting the stained part.
About initial treatment for breast cancer
Treatment of breast cancer involves a combination of surgery, radiation therapy, and drug therapy (endocrine therapy, chemotherapy, molecular-targeted therapy, etc.). This is called “multidisciplinary therapy”. Each treatment is described below.
The size of the lump that can be treated with breast-conserving surgery is generally considered to be 3 cm or less, considering the size of the Japanese breast and the shape of the breast after resection.
The size of the lump that can be treated with breast-conserving surgery is generally considered to be 3 cm or less, considering the size of the Japanese breast and the shape of the breast after resection. In addition, even if the size is 3 cm or less, if an ulcer is formed on the skin in the same area, if the skin is discolored, or if the nipple is pulled in near the nipple and depression is observed, breast preservation is advised. Surgery is difficult. However, in some cases, such as when drug therapy is performed before surgery and therapeutic effects such as tumor shrinkage are obtained, conservative surgery may be possible.
There is a risk of cancer developing in the breast that is preserved (local recurrence). Therefore, radiotherapy is the standard treatment after conserving surgery. Local recurrence is said to be reduced to about one-third by irradiation.
Mastectomy is performed for those who are not suitable for breast-conserving surgery due to special illnesses or those who have already undergone radiation therapy, or for those who did not wish to have breast-conserving surgery. Depending on the indication, consideration will be given to cosmetology, such as a subcutaneous mastectomy that preserves the nipple and areola or a skin-sparing mastectomy.
Mastectomy is performed for those who are not suitable for breast-conserving surgery due to special illnesses or those who have already undergone radiation therapy, or for those who did not wish to have breast-conserving surgery. Depending on the indication, consideration will be given to cosmetology, such as a subcutaneous mastectomy that preserves the nipple and areola or a skin-sparing mastectomy. In principle, the pectoral muscle is preserved, but pectoral muscle joint resection may be performed as necessary, such as when cancer spreads to the pectoral muscle.
We will also talk about breast reconstruction surgery in cooperation with Plastic Surgery. There are cases in which the breast is reconstructed at the same time as the mastectomy (primary reconstruction), and in cases where it is reconstructed after a period of time (secondary reconstruction). There is a one-stage reconstruction, such as inserting an implant at the same time in one reconstruction, and a two-stage reconstruction, such as inserting a tissue expander at the time of reconstruction first to spread the skin and then replacing it with an implant. For reconstruction, autologous tissue (lattis dorsi or rectus abdominis muscle flap) or implants may be used.
The sentinel lymph nodes (sentinel lymph nodes or sentinel lymph nodes) are the few lymph nodes that are thought to be the first to spread if breast cancer spreads to the lymph nodes in the armpit. A sentinel lymph node biopsy removes a few of these lymph nodes.
The sentinel lymph nodes (sentinel lymph nodes or sentinel lymph nodes) are the few lymph nodes that are thought to be the first to spread if breast cancer spreads to the lymph nodes in the armpit. A sentinel lymph node biopsy removes a few of these lymph nodes.
Methods for finding the sentinel lymph node include injecting a radioactive isotope around the areola and injecting a dye (such as ICG). At our hospital, we use these methods to find sentinel lymph nodes. In the past, when there was metastasis in the sentinel lymph node, all the lymph nodes under the arm were removed (dissection is a technical term). Currently, even if there is metastasis in the sentinel lymph node, we select cases and omit dissection. Also, if there is no metastasis in the sentinel lymph node, dissection is omitted.
Whether there is metastasis in the sentinel lymph node is examined by rapid pathological examination during surgery or by permanent pathological examination over a period of about two weeks. This sentinel lymph node biopsy was developed with the aim of reducing sequelae after lymph node dissection, such as numbness and pain on the inside of the upper arm that increases when dissection is performed, and refractory edema in the forearm and entire upper arm.
Hormone therapy reduces estrogen, a female hormone produced in the body by using hormone treatment drugs, and reduces estrogen receptors in breast cancer (like intakes for estrogen). It interferes with the binding of estrogen to prevent cancer growth.
Hormone therapy reduces estrogen, a female hormone produced in the body by using hormone treatment drugs, and reduces estrogen receptors in breast cancer (like intakes for estrogen). It interferes with the binding of estrogen and prevents cancer growth. The purpose of this treatment is to control breast cancer cells hidden somewhere in the body after surgery and prevent recurrence. Since treatment will continue for 5 to 10 years, please fully understand the significance and side effects of hormone therapy before starting treatment.
Cancer cells have a high proliferative ability (fast growth rate), and hormone therapy alone is considered insufficient to prevent recurrence (genetic testing may be used to determine this), or hormone therapy is indicated in the first place. It is performed for those who do not have breast cancer. The goal is to prevent recurrence.
Cancer cells have a high proliferative ability (fast growth rate), and hormone therapy alone is considered insufficient to prevent recurrence (genetic testing may be used to determine this), or hormone therapy is indicated in the first place. It is performed for those who do not have breast cancer. The goal is to prevent recurrence.
Anticancer agents such as anthracyclines and taxanes are often used, but the drug is selected according to the individual patient's condition. Side effects include hair loss, malaise, loss of appetite, numbness in the hands and feet, and decreased blood counts. At our hospital, we work closely with the Oncology, chemotherapy-certified nurses, and specialist pharmacists to ensure that patients can receive chemotherapy with peace of mind.
Molecular-targeted therapy is a treatment method that targets specific molecules that are thought to be involved in the development and progression of breast cancer.
Molecular-targeted therapy is a treatment method that targets specific molecules that are thought to be involved in the development and progression of breast cancer.
Detailed characteristics of breast cancer are examined by needle biopsy before surgery and pathological diagnosis after surgery to determine whether molecular target therapy is indicated. For example, for HER2-positive breast cancer, antibodies and low-molecular-weight compounds are used as anti-HER2 treatments. Often used in combination with chemotherapy. Immune checkpoint inhibition therapy, which is cancer immunotherapy, can also be said to be a molecular target therapy in a broad sense. In addition, various molecular-targeted drugs have been developed and actually used. We will propose a treatment method that is suitable for each individual patient.
Dealing with familial tumors, hereditary tumors, etc.
When there is an abnormal cluster of cancers in a family, regardless of the cause, the clustered tumors are called familial tumors. When certain genes are strongly involved in tumor development, it is called a hereditary tumor. For example, it is known that breast cancer and ovarian cancer are cancers caused by gene mutations called BRCA. Familial tumors, hereditary tumors, etc. will be handled in cooperation with obstetrics and Obstetrics and Gynecology, Plastic Surgery, genetic counselors, etc. We also have a hereditary tumor outpatient clinic, so you can visit us there.
clinical research
For patients undergoing Breast Surgery
Notice Regarding Implementation of Clinical Research
Breast Surgery is currently conducting the following clinical studies.
In this research, we will use the data (information) obtained from the patient's daily clinical practice.
If you object to the use of your data for this research, you can stop using the information or providing it to other research institutions at any time. If you would like to know more about the research plan or content, if you have any objections to the use of your data in this research, or if you have any other questions, please contact us at the contact information below. .
Research subject title: Exploratory research on molecular biological mechanisms involved in breast cancer microenvironment formation using biological samples
Our department is conducting joint research with Kyoto University Graduate School of Medicine to conduct exploratory research on the molecular biological mechanisms involved in breast cancer microenvironment formation using biological samples.
Please see here for the detail.clinical research
Research subject name | Person in charge of our hospital | approval date | Explanatory text (PDF) |
---|---|---|---|
Examining the use of CDK4/6 inhibitors in breast cancer patients with BRCA pathogenic variants: a retrospective cohort study | Nina Odan | 2024/3/1 | |
De-escalation therapy and prognosis in the elderly: retrospective cohort study | Mako Ikeda | 2023/10/3 | |
Cohort study on follow-up treatment after discontinuation of trastuzumab deruxtecan in patients enrolled in "Enherts Intravenous Infusion 100 mg Specified Drug Use (Breast Cancer)" | Sayaka Takebe | ||
Surgery and treatment information database project in the National Clinical Database (NCD) | Eiji Suzuki | ||
Current status of BRCA genetic testing at our hospital | Eiji Suzuki | 2021/9/17 |