Information on Genome & Genetics Center
Greetings from the Center Director
In recent years, it has become clear that genetic changes and genetic predispositions are involved not only in cancer but also in many diseases and pathological conditions, and genetic treatment and genetic counseling, including cancer treatment based on genetic information, are becoming more commonplace. It has become an important presence.
The Genetic Center was established in 2022 as one of the multidisciplinary medical departments with the aim of unifying the system of cancer genomic medicine and genetic medicine and strengthening cooperation with related medical departments.
At the Cancer Genome Testing Outpatient Clinic, we conduct cancer gene panel tests (cancer genome profiling tests) in order to practice cancer genome medicine beyond the boundaries of clinical departments. At the Genetic Counseling Outpatient Clinic, we handle a wide range of genetic diseases, not just hereditary tumors. We also offer consultations regarding genetic testing. At the Perinatal Genetic Consultation Outpatient Clinic, we provide genetic counseling and testing for non-invasive prenatal genetic testing (NIPT).
We will strive to provide easy-to-understand explanations to patients so that they can receive examinations and treatments with peace of mind.
Director of Genetic Center
Hisaaki Yasui
What is heredity
Even though every blood family is different, why are they all similar in some way?
About genetic counseling
Genetic counseling is intended for these individuals.
Characteristics of genetic centers
Cancer genomic testing outpatient
About Cancer and Genetics
genetic counseling outpatient
In addition, we have established a system that allows us to perform risk-reducing surgery.
Perinatal Genetic Counseling Outpatient
constituent member
Cancer genomic testing outpatient
What is cancer genomic medicine?
Using cancer tissue, etc., a large number of cancer-related genes are examined simultaneously (cancer gene panel test), and by clarifying gene changes, treatment etc. is tailored to each individual's tumor characteristics and medical condition. It is medical to do. If changes in specific genes play an important role in cancer growth (driver genes), drugs that suppress the activity of those genes (molecular-targeted drugs, etc.) may be effective. . It will be possible to select drugs based on genetic changes in cancer cells, rather than the conventional standard treatment according to the primary organ.
Cancer genome test (cancer gene panel test) conducted at our hospital
After determining whether the patient's general condition is ready for testing, doctor determine whether or not the patient can undergo a cancer genome test. First, check with your doctor to see if you are eligible for the test.
*Of this, 10-30% will be your own expense.
Eligible for the high-cost medical care benefit system
Specimen condition
This test requires nucleic acid samples from cancer tissue for genetic analysis. Therefore, we ask that you provide a pathological block of tissue containing cancer (*) or a formalin-fixed paraffin-embedded (FFPE) section.
(*) Tissue containing cancer: Use a biopsy sample for pathological examination of cancer or a tissue sample collected during surgery (preferably within 48 hours of formalin immersion and within 3 years after collection) ).
Flow of cancer genome testing
At our hospital, it takes about 1 to 2 months from the outpatient consultation for cancer genome testing to the explanation of the results. Genetic information returned from specialized analysis institutions is examined by an expert panel of experts familiar with cancer genomic medicine to determine whether there is a treatment or clinical trial that is suitable for the patient. explain the results. As a cancer genome medical collaborating hospital, our hospital has a tie-up with Kyoto University Hospital, a core hospital for cancer genomic medicine.
Things to keep in mind
Cancer genomic medicine has not only various advantages but also disadvantages. At the cancer genome testing outpatient clinic, we not only explain the test and results, but also take time to carefully explain the merits, demerits, and limitations of the test, and discuss together with the patient what options are available. I will think about it.
There are several points to keep in mind for cancer genomic testing, including:
Possibility of sample failure
Testing does not guarantee 100% success. The test itself may be unsuccessful due to reasons such as the poor condition of the specimen.
Unable to find effective therapeutic drugs / Possibility of not finding therapeutic drugs covered by insurance
Testing may provide information to help guide future treatment choices. On the other hand, even with cancer genome testing, only about 10 to 20% of patients can actually be treated due to reasons such as the lack of approved drugs. There are few clinical trials and advanced medical treatments based on genetic alterations, and there is the problem of extremely high costs when using unapproved drugs off-label.
Possibility of revealing innate constitution (susceptibility to cancer)
About 10% of cancers are known to be hereditary tumors, which are caused by a predisposition to develop cancer. Cancer genomics tests have a small percentage chance of finding genetic alterations associated with hereditary tumors.
At our hospital, we have a system in place to discuss various questions that arise when a hereditary tumor is suspected, together at the genetic counseling outpatient clinic.
Providing information to C-CAT
By registering the data used in cancer genome testing with C-CAT, it is possible to obtain information useful for medical treatment, such as information on drugs and clinical trials. It will also be useful for the development of new therapeutic drugs in the future.
Cancer genome test application method
Cancer genomic testing outpatient is only available on Tuesday afternoons.
If you are visiting our hospital
Please consult your doctor.
If you have not visited our hospital
After consulting with your family doctor, please have your family doctor make a fax appointment in advance.
Documents required for FAX reservation are "medical information provision form" and "additional interview items". Please send a fax to our Regional Medical Cooperation Center (FAX: 078-302-2251).
| medical information sheet | |
| Additional question items |
genetic counseling outpatient
Genetic Counseling Outpatient
Please make a reservation in advance when visiting the hospital. Depending on the content of the consultation, the treatment may be covered by insurance or not covered by insurance (own expense). On the day of genetic counseling, please come directly to the reception desk on the 2nd floor of the South Building of our clinic.
*From the point of view of personal information, we may not be able to respond to consultations regarding the illness of people other than the family of the caller.
For those planning to receive genetic counseling
Genetic counseling is a place to discuss what is necessary to live with "diseases and constitutions related to genes".
Outpatient day and cost
Day of the week: Every Friday
Cost: Depending on the content of the consultation, treatment may be covered by insurance or not covered by insurance (own expense).
In the case of non-insured (self-financed) medical care, the following applies.
- First 60 minutes: 11,000 yen (tax included)
- Every 15 minutes after the second time: 2,750 yen (tax included)
*Additional fees are required for examinations and consultations with other departments. The cost of the test will be announced during genetic counseling.
What to bring on the day
- Health insurance card
- letter of introduction
On the day of the event, we will check your family history as much as possible and create a family tree.
Considerations
We basically handle all disease areas, but we cannot accept paternity tests.
After receiving your reservation, we may contact you by phone to confirm the details of your consultation.
In addition, as a general rule, please visit the department in charge of our hospital before and after genetic counseling.
We recommend that you consult with us regarding your treatment policy.
Reservation method
Reservations are required for outpatient genetic counseling.
If you are already in a hospital, please make a reservation by fax through your doctor. When making a reservation, a fax reservation application form and a medical information provision form are required.
Click here for the PDF fax reservation application form, and click here for the WORD form.
If you do not have a family medical institution (if you are considering a blood relative diagnosis), please contact the person in charge below directly. For consanguineous testing, we need a copy of your family's genetic test results.
To everyone who is considering blood relative diagnosis
Hospital main number: 078-302-4321 (reception: weekdays 9:00-17:00)
Person in charge: Hayashi (genetic counseling doctor)
clinical research
| Research subject name | responsible doctor | approval month | Explanatory text |
| Creating a database of BRCA genetic tests | Nobutaka Hayashi | March 2024 |
Perinatal Genetic Counseling Outpatient
NIPT
Recently, in the field of Obstetrics and Gynecology, awareness of NIPT (Non-Invasive Prenatal Genetic Testing), a test that uses maternal blood to check for specific fetal chromosomal abnormalities before birth, is spreading, and our hospital has also established a system to implement it. We have an accredited infrastructure and offer genetic counseling and testing.
NIPT examines the possibility of the baby having a chromosomal disorder (trisomy 21, trisomy 18, trisomy 13) by examining maternal blood. Undergoing NIPT is an option when the incidence of these chromosomal disorders is high:
- elderly pregnant women
- If maternal serum marker testing suggests the baby may have a chromosomal abnormality
- Pregnant women with a history of pregnancies with babies with chromosomal abnormalities
- One parent has a balanced Robertsonian translocation, suggesting that the baby may have trisomy 13 or trisomy 21
- If fetal ultrasound suggests the baby may have a chromosomal abnormality
However, regardless of the frequency of occurrence of the target disease, for pregnant women whose concerns about chromosomal abnormalities in their babies cannot be resolved even after genetic counseling, we will provide sufficient information and support before making decisions on their own. will be honored.
Target audience and location
NIPT is intended for pregnant women between 10 and 14 weeks of gestation with a single or twin pregnancy.
Genetic counseling and testing are available at the perinatal genetic counseling outpatient clinic.
Reservation method
Reservations and information for the perinatal genetic consultation outpatient clinic are available at the Obstetrics Outpatient Department of our hospital.
・ Those who are visiting the obstetrics outpatient department of our hospital If you wish to have NIPT at , please consult your doctor.
・ Other hospital family If you wish to have NIPT at our hospital, please consult your obstetrician Obstetrics and Gynecology.
Please make an appointment to see an obstetrician outpatient at our hospital.
news
access
For access to our hospital, please click here.
We have a main building and a south building. Genetic counseling is available on the 2nd floor of the South Building. After exiting the Iryo Center station ticket gate and going straight to the left, you will find the entrance on the 2nd floor of the South Building.
Please go to the reception desk at the entrance on the 2nd floor of the South Building to complete the procedures for visiting the hospital.
Link
Society of genetics
・ The Japan Society of Human Genetics
・ Japan Society of Genetic Counseling
・ The Japanese Society for Hereditary Tumors
Cancer genomic testing outpatient
・ Cancer genomic medicine and cancer gene panel testing
・ Tell me about cancer genomic medicine
・ The story of cancer gene panel testing
Perinatal Genetic Counseling Outpatient
・ Let's think together, examination of the baby in the stomach
